Treatment of metformin-associated lactic acidosis with sustained low-efficiency daily dialysis
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چکیده
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منابع مشابه
Sustained low-efficiency dialysis as a treatment modality in a patient with lymphoma-associated lactic acidosis.
Lactic acidosis is a potentially life-threatening metabolic disorder, initiated by an imbalance between lactic acid production and utilization. The only effective treatment is reversal of the cause of the disordered lactic acid metabolism [1]. Intravenous bicarbonate (HCO3 ) administration is often used as an interim treatment to attempt to ameliorate the effects of the acidosis, particularly v...
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BACKGROUND Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant increase in hospitalizations for MALA to our Center. We report the outcomes of our clinical and therapeutic approach. METHODS This is a single-center case series. Twenty-eight ...
متن کاملBerberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusi...
متن کاملAcute metformin intoxication: diagnosis, management and prognosis
Background: Metformin intoxication can potentially originate a lactic acidosis of variable severity, but possibly fatal, diagnosis and prompt treatment of which are crucial. The difficulty in establishing a clear cause and effect relationship arises from the multitude of biologic actions exerted by metformin. Objective: Review of literature in order to compile the current knowledge regarding th...
متن کاملShould dialysis be offered in all cases of metformin-associated lactic acidosis?
Metformin is commonly used in diabetes mellitus type 2, with lactic acidosis being a rare but potentially fatal complication of this therapy. The management of metformin-associated lactic acidosis (MALA) is controversial. Treatment may include supportive care, activated charcoal, bicarbonate infusion, hemodialysis, or continuous venovenous hemofiltration. In the previous issue of Critical Care,...
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